Article of Advances in Oncology Research 

To analyze the effect of melatonin on liver of rats induced by streptozotocin diabetes

Silva G.S.F1; Andrade F.L2, Melo I3, Maia C.S4; Tenorio B.M5, Tenório F.C.A.M6
1Estudante do Curso de Odontologia da Universidade Federal de Pernambuco– UFPE2Estudante do Curso de Medicina da Universidade Federal de Pernambuco- UFPE; 3Docente da Universidade IBGM- IBGM; 4Docente da Universidade Federal de Pernambuco-UFPE, Departamento de Histologia e Embriologia;, 5Docente da Universidade Federal de Alagoas- UFAL; 6Docente da Universidade Federal de Pernambuco-UFPE;

Hyperglycemia is the main feature of a group of metabolic diseases called diabetes mellitus. The pathophysiology of diabetes is directly related to pancreas and liver that is responsible for absorbing nutrients. To analyze the effect of melatonin on liver of rats induced by streptozotocin diabetes. The induction of diabetes was obtained by intraperitoneal injection of streptozotocin and test to confirm diabetes was carried out during 3 and 7 days after application. The melatonin treatment was performed at a dose of 200 μg/100g of animal body weight by injection. Morphometry was performed from a graduated graticule in the same points where focused on the liver of the rats in each group located. morphometric, livers showed no significant differences. Research suggests that melatonin acts indirectly by altering the secretion of insulin. Therefore, it was concluded that melatonin may play a role in the effective treatment of diabetes, as can arrive to reduce liver damage caused by morbidity caused by streptozotocin.

Diabetes; Glucose; Liver; Melatonin; Streptozotocin

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